Other names Tianeptine Sodium, Tianeptine Sulfate, Stablon
Tianeptine is a drug that has been studied in humans for its potential anti-depressant effects. Recently it has been gaining popularity among healthy self-experimenters who are trying to feel and perform better. Some people say it improves their energy levels, focus, and mood. But is it actually effective? And is it safe? Read on to find out what the science says.
This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Tianeptine.
Read about the effects of Tianeptine in relation to the amount of evidence we've found
Tianeptine for cognitive enhancement
Animal studies are a weak source of evidence on which to base nootropic use decisions. So let's look at some better evidence that exists on the effects of Tianeptine on cognitive performance.
In one study, healthy people were randomized to receive a single dose of tianeptine (12.5 mg) or placebo.  The results were:
"Tianeptine-treated subjects were less accurate at identifying facial expressions, though this was not valence specific. The tianeptine group also showed reduced positive affective memory and reduced attentional vigilance to positive stimuli. There were no effects on emotional categorization or non-emotional cognition."
This study is the only one that has examined the cognitive effects of Tianeptine in healthy humans, and the dose used was relatively small. The actual effects of Tianeptine in healthy humans looking to enhance cognitive performance with the drug is essentially unknown to science.
In another study, 164 patients with major depressive disorder were randomized into two groups. One group received 37.5mg Tianeptine daily and the other group received Escitalopram. Both groups had significant improvements in subjective cognitive impairment of memory and attention after 12 weeks.  After 12 weeks, patients in the Tianeptine group had improved verbal short term memory and reduced impulsivity when compared with Escitalopram, and improved long term memory, reasoning ability, and general cognitive functioning when compared with their own baseline. The improvement seen after 12 weeks compared with the participants' own baseline may have been due to the placebo effect and the improvements seen after 12 weeks when compared with the Escitalopram group may have been due to the lack of efficacy (or even negative effects) of Escitalopram on impulsivity and verbal short term memory.
Another study also examined the cognitive effects of Tianeptine in people with depression.  It was found that it improved short term memory and learning processes as well as reaction time and attention. However, there was no placebo control group in this study so a strong placebo effect cannot be ruled out.
Tianeptine for mood enhancement
Based on 18 studies that examined the effects of Tianeptine compared with the effects of other proven anti-depressants in people with depression, Tianeptine is as effective as these other proven anti-depressants. 
One study examined the effects of large doses of Tianeptine in healthy humans and found it as effective as Methylphenidate for improving mood. Methylphenidate is not used primarily for improving mood, but focus.
The legality and side effects of Tianeptine
Frequently asked questions about Tianeptine
Studies conducted on the effects of Tianeptine in healthy humans
Last updated Saturday, June 10, 2023