Yohimbine
This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Yohimbine.
Risks
The legality and side effects of Yohimbine
You should always consider the risks of a nootropic before you use it.
Side effects
Interactions
Supplements and drugs can interact with Yohimbine to increase or decrease the positive or negative effects you experience. If you are already using any supplements or drugs, speak with your trusted medical professional before you experiment with Yohimbine. To learn more about the potential interactions between Yohimbine and other substances, use interaction-checker.
Legality
Is your country not included? Learn how to find out if Yohimbine is legal in your country.
Legality Disclaimer
The contents herein are not legal advice or a substitute for legal counsel. information is not intended to create, and receipt of it does not constitute, an attorney-client relationship. While we have done our best to be as accurate as possible in the information we convey to you about the legality of nootropics, there is a risk for inaccuracies and errors. If you’re uncertain about the legality of any of your actions, contact a legal counsel or your local authorities governing the legality of various substances you may want to use/import/travel with.
Studies
Studies conducted on the effects of Yohimbine in healthy humans
No placebo-controlled trials on healthy humans that meet our inclusion criteria have been conducted on Yohimbine.
Summary
"Participants in the yohimbine group showed [...] better response inhibition [...] relative to the placebo group."
Summary
"There was a significant increase in panic symptoms in the yohimbine and Y+H groups but not in the hydrocortisone or placebo groups. Yohimbine resulted in a greater increase in panic symptoms than Y+H."
Summary
Yohimbine had no effect on decision-making under risk
Summary
"These effects are consistent with increased rapid-response impulsivity after pharmacological noradrenergic stimulation in healthy controls. Labile noradrenergic responses, or increased sensitivity to norepinephrine, may increase risk for impulsive behavior."
Summary
"These results are consistent with increased impulsivity in normal subjects given yohimbine, possibly related to increased norepinephrine."
Summary
"These results suggest that changes in noradrenaline (NA) activity affect both anxiety and arousal levels in high-anxiety humans, but predominantly affect only the arousal level in low-anxiety humans."
Summary
"YOH shifted the healthy subjects' mood towards feeling panicked, elevated systolic blood pressure and plasma prolactin concentrations, reduced digit symbol substitution, and induced drowsiness and passiveness."
Summary
These results do not support the hypotheses that high aerobic fitness is associated with attenuated psychological and neuroendocrine responses to yohimbine or to psychosocial stress.
Summary
Yohimbine significantly elevated, and metoprolol reduced mean heart rate during the slide show relative to placebo, thus confirming the efficacy of the pharmacological manipulation. One week later, in a surprise' test, memory for the slide show was tested. As predicted, yohimbine-treated subjects recalled significantly more and metoprolol subjects fewer slides relative to placebo. This result was confirmed via analysis of multiple-choice recognition memory scores.
Last updated Saturday, June 10, 2023