Vitamin B6

Other names Pyridoxine, Pyridoxal 5′-phosphate, P-5-P, PLP,

Vitamin B6

Vitamin B6 is supplemented by some to improve brain functioning, but is it really effective for cognition and mood enhancement? Read on to find out what the science says.

This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Vitamin B6.


Read about the effects of Vitamin B6 in relation to the amount of evidence we've found

Why do people use vitamin B6?

People who self-experiment with vitamin B6 often state they use it to improve their:

  • Memory
  • Focus
  • Mood
  • Sociality

There is a lack of scientific evidence for the effectiveness of vitamin B6 for any of these purposes, especially in healthy humans.

Vitamin B6 for cognitive enhancement

There's a lack of evidence on the efficacy of vitamin B6 as a cognitive enhancer, but preliminary research suggests it is ineffective.

In a systematic review, it was concluded that there is not enough evidence for the efficacy of supplementation with vitamin B6 for the enhancement of any cognitive functions in the short term. [1]

The authors of the systematic review found two studies on the cognitive effects of vitamin b6 in elderly people:

"Twelve healthy women aged 65 to 92 years received 75 mg vitamin B6 orally per day and were compared with 21 healthy women who were allocated to placebo. No statistically significant benefits from vitamin B6 on mood or cognition were observed." [2]

In the second study analyzed in the systematic review, 38 participants received 20mg vitamin B6 daily for 12 weeks. No beneficial effects on mood or cognition were found in this study either. [3]


The legality and side effects of Vitamin B6


Frequently asked questions about Vitamin B6


Studies conducted on the effects of Vitamin B6 in healthy humans

Last updated Saturday, June 10, 2023