Other names L-Tryptophan


Tryptophan is an amino acid found naturally in many foods. It is supplemented by some people to improve mood and reduce nervousness and stress. But is it effective? Read on to find out what the science says.

This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Tryptophan.


Read about the effects of Tryptophan in relation to the amount of evidence we've found

Why do people use tryptophan?

People who self-experiment with tryptophan often state they use it to improve their:

  • Mood
  • Nervousness
  • Sleep
  • Mindfulness
  • Stress

There is a lack of scientific evidence for the effectiveness of tryptophan for any of these purposes, especially in healthy humans.

Can tryptophan improve your mood?

No studies have examined the effects of tryptophan on mood in healthy humans.

In a systematic review of tryptophan for clinical depression, it was found more effective than placebo. [1]

It is not known whether tryptophan, which increases serotonin levels in the brain, can improve mood in healthy humans or if it is only effective in bringing people with a disturbed mood back to a normal state.


The legality and side effects of Tryptophan


Frequently asked questions about Tryptophan


Studies conducted on the effects of Tryptophan in healthy humans

Last updated Saturday, June 10, 2023