Other names Arcalion, Vitamin B1 Derivative


Sulbutiamine is a vitamin B1 derivative which may improve focus, mood, and energy levels. But is it effective? Read on to find out what the science says.

This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Sulbutiamine.


Read about the effects of Sulbutiamine in relation to the amount of evidence we've found

Why do people use sulbutiamine?

People who self-experiment with sulbutiamine often state they use it to improve their:

  • Memory
  • Focus
  • Mood
  • Energy
  • Sociality
  • Learning

There is a lack of solid scientific evidence for the effectiveness of sulbutiamine for any of these purposes, especially in healthy humans.

Can sulbutiamine boost your energy levels?

No studies have examined the effects of sulbutiamine on energy levels in healthy humans.

In one study, 106 participants were given 400mg sulbutiamine daily for 28 days, and 111 participants were given 600mg for the same duration. Compared with the placebo, there were no benefits from the use of sulbutiamine, except for a day-7 reduction in fatigue in the 600mg group. It should be noted that the participants all suffered from chronic postinfectious fatigue, meaning that these findings are of questionable relevance to healthy humans. It should also be kept in mind that no effects were seen after 7 or 28 days for the 400mg group, or after 28 days in the 600mg group.

In another group of patients with infections and abnormally low energy levels, sulbutiamine improved well-being for the average person and completely removed the pathological lack of energy in around half of the patients [1].

In another study, [2] the use of 400mg sulbutiamine daily for two months resulted in physical, cognitive, and psychosocial functioning improvements in patients who had multiple sclerosis and fatigue and were treated for their disease by other means. It did not improve energy levels in patients who were not treated in another way for their disease.

These findings are promising, and more data should be collected on the effects of sulbutiamine in healthy people. But at this point, the evidence available says very little about the efficacy of sulbutiamine as an energy-booster in healthy people.

Will sulbutiamine improve your memory?

No studies have examined the effects of sulbutiamine on memory in healthy humans.

The combination of donepezil and sulbutiamine was more effective than donepezil and placebo in the preservation of episodic memory in patients with Alzheimer's disease [3]. Sulbutiamine did not improve working memory or executive functions but did improve attention. However, attention was also improved in the donepezil-only group so that effect may have been due to a placebo, or thanks to sulbutiamine.

As with any study conducted in diseased people, the transferability of the findings to practical applications in healthy humans is low, since the effects of the substance (in this case sulbutiamine), might only be protective. Protection from a decline in cognitive performance has been noted in studies on sulbutiamine, but not an enhancement of cognitive functions from a normal baseline.


The legality and side effects of Sulbutiamine


Frequently asked questions about Sulbutiamine


Studies conducted on the effects of Sulbutiamine in healthy humans

Last updated Saturday, June 10, 2023