Other names Pyrithioxine, Encephabol
Pyritinol is a compound used by some people to improve vigilance, memory, and learning. But is it really an effective cognitive enhancer? Read on to find out what the science says.
This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Pyritinol.
Read about the effects of Pyritinol in relation to the amount of evidence we've found
Pyritinol for cognitive enhancement
Twelve healthy males received 600mg pyritinol for three days, 1200mg pyritinol for three days, and a placebo for three days.  Participants completed a battery of psychological tests 1, 2, 4, and 6 hours after the first and third dose.
Pyritinol improved reaction time and the ability of participants to distinguish discrete sensory data. These findings are interesting because they suggest that pyritinol can put people into a mental state optimal for learning.
Pyritinol also improved vigilance in healthy humans in a study that hasn't been published online. 
In 67 children (11-16 years of age) with learning disabilities, 300mg pyritinol daily for 6 months was effective for some and had a negative impact on learning performance for others.  There were no beneficial effects of pyritinol overall in the group of children receiving it. It is not known why some people responded well and some responded poorly to pyritinol.
In a study on the effects of 800mg pyritinol daily for 3 or 6 months in patients with dementia, the 20 people who had received pyritinol had less cognitive impairment than the 20 patients who had received a placebo. 
These findings from studies in people with diseases may not transfer to healthy humans, so take them with a grain of salt.
Pyritinol for increased ability and motivation to socialize
Whether pyritinol can improve your sociality is not known, but preliminary evidence is promising.
Twelve weeks of daily consumption of 600mg pyritinol improved social behavior in 54 people with dementia compared with a placebo. 
The legality and side effects of Pyritinol
Frequently asked questions about Pyritinol
Studies conducted on the effects of Pyritinol in healthy humans
Last updated Saturday, June 10, 2023