Other names Dynamine
Methylliberine is a stimulating compound found naturally in the leaves of several plants. People report it improves their focus, mood, and energy. But is it effective? Read on to find out what the science says.
This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Methylliberine.
Read about the effects of Methylliberine in relation to the amount of evidence we've found
Why do people use Methylliberine?
Methylliberine is most commonly used to improve:
There's no solid scientific evidence yet to support the potential efficacy of Methylliberine for any of these purposes, and the one study that has been published showed no positive effects from Methylliberine.
Will methylliberine enhance your mood and energy levels?
There's not a single study published that objectively measured the potential beneficial Methylliberine effects in either diseased or healthy animals or humans.
There is one study in healthy humans that examined the subjective effects of Methylliberine. 
Visual analogue scales were used to measure the 12 participants' subjective attentiveness, energy levels, motivation, irritation, focus, jitteriness, and moodiness. Participants were asked to mark on scales between 0 and 100 how they felt at the present moment at baseline and 0.25, 0.5, 1, 1.5, 2, 4, 6, 8, 24, and 48 hours post-dose.
The study authors concluded that 25 or 100mg Methylliberine seemed to have "little impact on subjective mood". There was no placebo control condition in this study, but there was a Caffeine control group. Based on the evidence available, Caffeine appears more effective than Methylliberine for enhancement of essentially all aspects of subjective mood.
The developer of the trademarked version (Dynamine) of Methylliberine, Compound Solutions, appears to have several human trials in the pipeline. 
The legality and side effects of Methylliberine
Frequently asked questions about Methylliberine
Studies conducted on the effects of Methylliberine in healthy humans
Last updated Saturday, June 10, 2023