Other names Ergoloid Mesylates


Hydergine is a drug used in the treatment of some forms of cognitive impairment. It is also used by some healthy people as a cognitive enhancer. But is it a safe and effective nootropic? Read on to find out what the science says.

This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of Hydergine.


Read about the effects of Hydergine in relation to the amount of evidence we've found

Is Hydergine an effective nootropic for cognitive enhancement?

Hydergine is the brand-name for ergoloid mesylates, which are fungus-derived compounds.

The drug is likely effective in people diagnosed with dementia. [1]

But can it enhance cognitive functions in healthy people?

The only study available on the effects of Hydergine in healthy people examined its effects in the elderly.

The study compared 1.5mg Hydergine tablets 3 times daily with a placebo. Results were collected and analyzed after 3 and 5 years.

Compared with the placebo group, participants in the Hydergine group performed better cognitively at the end of the 5-year-period [2] (and after 3 years [3]).

It is not certain that the effects found were true enhancements of cognitive functioning. In fact, the authors of the 5-year follow-up article concluded:

"... ergoloid mesylates was partly effective in maintaining physical and mental health in these healthy elderly individuals."

Note the word "maintaining". The researchers could've easily chosen a word like "enhancing" or "improving" if it better described the effects that were found. Based on the available evidence, Hydergine appears to reduce cognitive decline, not enhance cognition from a healthy baseline.

Hydergine is likely effective for the protection of cognitive functions from deterioration in some neurological diseases. The research that we would need to definitively answer the question of whether Hydergine is effective for cognitive enhancement in healthy people has not been conducted yet.


The legality and side effects of Hydergine


Frequently asked questions about Hydergine


Studies conducted on the effects of Hydergine in healthy humans

Last updated Saturday, June 10, 2023