Other names Choline Alfoscerate, L-Alpha Glycerylphosphorylcholine


Alpha-GPC is a choline source which increases acetylcholine in the brain. Acetylcholine is known as ”the memory neurotransmitter”. But do Alpha-GPC supplements actually improve memory or any other aspects of cognition? Read on to find out what the science says.


Read about the effects of Alpha-GPC in relation to the amount of evidence we've found

Alpha-GPC for cognitive performance

In an analysis of 10 studies on the effects of Alpha-GPC in 1570 patients with dementia, it was found that Alpha-GPC significantly improved cognitive symptoms of the condition. Specifically, it improved memory and attention). [1]

Despite its widespread use among healthy young adults as a nootropic, no studies have examined its cognitive effects for healthy people.

Alpha-GPC appears to improve cognition in people with cognitive impairment, but it is not known whether it improves cognition for people with an already healthy baseline.

Alpha-GPC for improved energy and physical performance

We analyzed data from 1 placebo-controlled study on the effects of Alpha-GPC in healthy humans and summarized the results here:

EffectEffect sizeEvidence amount
Minute positive


The legality and side effects of Alpha-GPC

How To Use

Dose, frequency and duration


Frequently asked questions about Alpha-GPC


Studies conducted on the effects of Alpha-GPC in healthy humans

Last updated Saturday, June 10, 2023