Other names 5-Hydroxytryptophan, Oxitriptan


5-HTP is converted into serotonin in your body. It is supplemented by some people to improve mood and reduce nervousness and stress. But is it effective? Read on to find out what the science says.

This nootropic has no healthy human placebo-controlled studies that meet our inclusion criteria. Negative side effects can occur if used carelessly, so make sure you’re aware of the risks of 5-HTP.


Read about the effects of 5-HTP in relation to the amount of evidence we've found

Can 5-HTP improve your mood?

Only one study examined the effects of 5-HTP on mood in healthy humans, and it found no beneficial effects.

In a systematic review of 5-HTP for clinical depression, it was found more effective than placebo [1].

It is not known whether 5-HTP, which increases serotonin levels in the brain, can improve mood in healthy humans or if it is only effective in bringing people with a disturbed mood back to a normal state.

In the one study which has examined the effects of 5-HTP on mood in healthy humans, 100mg had no acute beneficial effects on mood [2].


The legality and side effects of 5-HTP


Frequently asked questions about 5-HTP


Studies conducted on the effects of 5-HTP in healthy humans

Last updated Saturday, June 10, 2023